Again, your friend needs to consult the law in her area to determine
exactly what requirements are needed to set the document into effect.
The document is likely to say that it comes into effect when your
friend becomes incapable of making certain decisions. She can specify
the people who she wishes to make that decision, for example, two
physicians.
The law may also define exactly what is deemed to be incapacity
to make decisions. For example, the Personal Directives Act
of Alberta describes capacity as the ability to understand information
that is relevant to making a personal decision with the competence
to appreciate the reasonable foreseeable consequences of the decision.